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Donald Douglas DuBose (born March 14, 1964) is an American former professional football player who was a running back for two seasons with the San Francisco 49ers of the National Football League (NFL). He played college football for the Nebraska Cornhuskers. DuBose was a member of the 49ers team that won Super Bowl XXIII. He also played for the Sacramento Surge of the World League of American Football (WLAF).

DuBose attended Montville High School in Oakdale, Connecticut.

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