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Chemical compound
Tampramine (AHR-9,377) is a tricyclic antidepressant (TCA) which was developed in the 1980s but was never marketed.[1][2] Despite being a TCA, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic, histaminergic, and muscarinic receptors.[1] It was found to be effective in the forced swim test (FST) model of depression in animal studies but is not known to have ever been trialed in humans.[2]
See also
References
- ^ a b Kinnier WJ, Tabor RD, Norrell LY (October 1984). "Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake". Biochemical Pharmacology. 33 (19): 3001–5. doi:10.1016/0006-2952(84)90600-2. PMID 6548381.
- ^ a b O'Donnell JM, Seiden LS (1985). "Effect of the experimental antidepressant AHR-9377 on performance during differential reinforcement of low response rate". Psychopharmacology. 87 (3): 283–5. doi:10.1007/BF00432708. PMID 3936083. S2CID 20677730.
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Classes | |
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Antidepressants (Tricyclic antidepressants (TCAs)) |
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Antihistamines |
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Antipsychotics |
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Anticonvulsants | |
Anticholinergics | |
Others |
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