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by | Mar 21, 2018 | Verbena

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Fosfluconazole (INNTooltip International Nonproprietary Name) is a water-soluble phosphate prodrug of fluconazole[1] — a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.[2]

The phosphate ester bond is hydrolyzed by the action of a phosphatase — an enzyme that removes a phosphate group from its substrate by hydrolyzing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (dephosphorylation).[3]

References

  1. ^ Bentley A, Butters M, Green SP, Learmonth WJ, MacRae JA, Morland MC, O'Conno G, Skuse J (2002). "The Discovery and Process Development of a Commercial Route to the Water Soluble Prodrug, Fosfluconazole". Organic Process Research & Development. 6 (2): 109–112. doi:10.1021/op010064+. ISSN 1083-6160.
  2. ^ Takahashi D, Nakamura T, Shigematsu R, Matsui M, Araki S, Kubo K, et al. (2009-05-25). "Fosfluconazole for antifungal prophylaxis in very low birth weight infants". International Journal of Pediatrics. 2009 (2009): 274768. doi:10.1155/2009/274768. PMC 2778452. PMID 19946419.
  3. ^ Lee CC, Schrier WH, Nagyvary J (January 1979). "The enzymatic hydrolysis of the phosphate ester bond in some thionucleotides". Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. 561 (1): 223–231. doi:10.1016/0005-2787(79)90505-7. PMID 84687.
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