Trumpet Vine – Campsis radicans

by | Dec 19, 2023 | Trumpet Vine

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3-Methyl-GABA, also known as HMS3266K11, is an anticonvulsant alkaloid.

Pharmacology

3-Methyl-GABA is an activator of GABA-T, an enzyme that transforms GABA to succinate semialdehyde and glutamate.[1]

It also activates glutamate decarboxylase, an enzyme that is needed in GABA synthesis. This is thought to be the primary mechanism of action behind its anticonvulsant action.[2][3]

References

  1. ^ https://www.tocris.com/products/3-methyl-gaba_0386
  2. ^ https://www.medchemexpress.com/3-methyl-gaba.html
  3. ^ Silverman, Richard B.; Andruszkiewicz, Ryszard; Nanavati, Shrenik M.; Taylor, Charles P.; Vartanian, Mark G. (1991). "3-Alkyl-4-aminobutyric acids: The first class of anticonvulsant agents that activates L-glutamic acid decarboxylase". Journal of Medicinal Chemistry. 34 (7): 2295–2298. doi:10.1021/jm00111a053. PMID 2067001.
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