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Chemical compound
Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ1 and δ2 subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors.[1] It also acts as a κ-opioid agonist at high doses.[2]
See also
References
- ^ Sofuoglu M, Portoghese PS, Takemori AE (May 1991). "Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes". The Journal of Pharmacology and Experimental Therapeutics. 257 (2): 676–80. PMID 1851833.
- ^ Stewart PE, Holper EM, Hammond DL (1994). "Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes". Life Sciences. 55 (4): PL79-84. doi:10.1016/0024-3205(94)00738-1. PMID 8028443.
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