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by | Mar 21, 2018 | Thuja

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Enduracididine is a non-proteinogenic α-amino acid that is a cyclic analogue of arginine.[1] It is not genetically encoded into peptide sequences, but rather is generated as a posttranslational modification.

Biological roles

Enduracididine occurs rarely in nature, appearing principally in peptide antibiotics such as the antibacterial compounds enramycin and teixobactin.[2]

References

  1. ^ Atkinson, DJ; Naysmith, BJ; Furkert, DP; Brimble, MA (7 November 2016). "Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis". Beilstein J Org Chem. 12: 2325–2342. doi:10.3762/bjoc.12.226. PMC 5238550. PMID 28144300.
  2. ^ Ling, LL; Schneider, T; Peoples, AJ; Spoering, AL; Engels, I; Conlon, BP; Mueller, A; Schäberle, TF; Hughes, DE; Epstein, S; Jones, M; Lazarides, L; Steadman, VA; Cohen, DR; Felix, CR; Fetterman, KA; Millett, WP; Nitti, AG; Zullo, AM; Chen, C; Lewis, K (22 January 2015). "A new antibiotic kills pathogens without detectable resistance". Nature. 517 (7535): 455–9. doi:10.1038/nature14098. PMC 7414797. PMID 25561178.
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