SoRI-9804 is a positive allosteric modulator of dopamine transporters. Unlike others in its series & traditional DRI ligands, it inhibits the release of dopamine in addition to inhibiting the reuptake of released dopamine back into the transporter.[1]

See also

References

  1. ^ Rothman, Richard B.; Dersch, Christina M.; Ananthan, Subramaniam; Partilla, John S. (May 2009). "Studies of the biogenic amine transporters. 13. Identification of "agonist" and "antagonist" allosteric modulators of amphetamine-induced dopamine release". Journal of Pharmacology and Experimental Therapeutics. 329 (2): 718–28. doi:10.1124/jpet.108.149088. PMC 2672863. PMID 19244097.