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ISS is an abbreviation for the International Space Station.
ISS may also refer to:
Organisations
- Institute for Science and Society, an academic department at the University of Nottingham, England
- Institute for Security Studies, Pretoria, South Africa studying crime, corruption, and conflict in Africa
- Institute of Social Studies, an international institute in The Hague, the Netherlands
- International Social Service, a charitable, non-governmental organisation
- Information Systems & Services, a former part of the UK Ministry of Defence
- Internal Security Service, national security intelligence agency of Oman
- Istituto Superiore di Sanità, the Italian National Institute of Health
- Intercollegiate Socialist Society (1905–1921), an American political youth organization
Businesses
- ISS A/S, a Danish service company
- Institutional Shareholder Services, a proxy advisory firm
- Internet Security Systems, a security software vendor
Arts, entertainment, and media
- I.S.S. (film), an American science fiction thriller film
- International Staff Songsters, the flagship choir of the Salvation Army
- International Superstar Soccer, a video game series
- Idea Star Singer, a Malayalam music reality show by Asianet TV
- Imperial Star Ship, a fictional spaceship designation prefix in Star Trek's Mirror Universe
Education
- ISS International School, an international school in Singapore
- In-school suspension, a form of discipline used in some schools
- Instituto San Sebastián Yumbel, Chilean school in Yumbel, Chile
Science and technology
- Ion scattering spectroscopy or low-energy ion scattering, a materials analysis method
- Imaging Science Subsystem, Cassini–Huygens space probe instruments
- Instruction set simulator, a computer program that simulates a processor
- International Seismological Summary, an earthquake catalog
- Input Shaft Speed sensor, a sensor that measures the rotational speed of the input shaft in a vehicle
Medicine
- Idiopathic short stature, an unexplained short stature
- Injury Severity Score
- International Staging System, for the severity of multiple myeloma
Other uses
- Independent Subway System, a former rapid transit rail system in New York City, US
- Islamic State in Somalia, a faction of the Islamic State of Iraq and the Levant
- ISS Hockey (International Scouting Services), ice hockey scouting service
- Air Italy (2005–2018) (ICAO: ISS), a defunct Italian airline
- IShowSpeed (born 2005), American YouTuber
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