Taxus Baccata

by | Mar 15, 2018 | Taxus Baccata

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Hydroxymatairesinol (HMR) is a lignan found in Norway spruce (Picea abies).[1] It is an enterolactone precursor with anticancer activities. In rats, HMR decreased the volume of induced tumours and stabilised established tumours, as well as preventing the development of new tumours.[1] It has also shown anti-oxidant properties in vitro.[1]

HMR's chemical structure is similar to matairesinol.[2] At high concentrations, HMR has estrogenic properties, which are considerably weaker than those of estradiol.[2]

References

  1. ^ a b c Saarinen, NM; Warri, A; Makela, SI; et al. (2000). "Hydroxymatairesinol, a novel enterolactone precursor with antitumor properties from coniferous tree (Picea abies)". Nutrition and Cancer. 36 (2): 207–16. doi:10.1207/S15327914NC3602_10. PMID 10890032. S2CID 22124446.
  2. ^ a b Cosentino, M; Marino, F; Ferrari, M; et al. (August 2007). "Estrogenic activity of 7-hydroxymatairesinol potassium acetate (HMR/lignan) from Norway spruce (Picea abies) knots and of its active metabolite enterolactone in MCF-7 cells". Pharmacological Research. 56 (2): 140–7. doi:10.1016/j.phrs.2007.05.001. PMID 17572100.


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