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Glionitrin A is an antibiotic-anticancer compound made by microbes found in an abandoned mine.[1] The total synthesis of (−)-glionitrin A was reported by Daniel Strand and co-workers in 2021.[2]
References
- ^ Park, H. B.; Kwon, H. C.; Lee, C. H.; Yang, H. O. (February 2009). "Glionitrin A, an antibiotic-antitumor metabolite derived from competitive interaction between abandoned mine microbes". J. Nat. Prod. 72 (2): 248–52. doi:10.1021/np800606e. PMID 19159274.
- ^ Koning, N.R.; Sundin, A.P.; Strand, D. (22 November 2021). "Total Synthesis of (−)-Glionitrin A and B Enabled by an Asymmetric Oxidative Sulfenylation of Triketopiperazines". J. Am. Chem. Soc. 143 (50): 21218–21222. doi:10.1021/jacs.1c10364. PMC 8704193. PMID 34808045.
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