Heritability is the proportion of variance caused by genetic factors of a specific trait in a population.[1] Falconer's formula is a mathematical formula that is used in twin studies to estimate the relative contribution of genetic vs. environmental factors to variation in a particular trait (that is, the heritability of the trait) based on the difference between twin correlations.[2] Statistical models for heritability commonly include an error that will absorb phenotypic variation that cannot be described by genetics when analyzed. These are unique subject-specific influences on a trait.[1] Falconer's formula was first proposed by the Scottish geneticist Douglas Falconer.[3]
The formula is
See also
References
- ^ a b Ge, Tian; Holmes, Avram J.; Buckner, Randy L.; Smoller, Jordan W.; Sabuncu, Mert R. (2017-05-08). "Heritability analysis with repeat measurements and its application to resting-state functional connectivity". Proceedings of the National Academy of Sciences. 114 (21): 5521–5526. Bibcode:2017PNAS..114.5521G. doi:10.1073/pnas.1700765114. ISSN 0027-8424. PMC 5448225. PMID 28484032.
- ^ Weber WW (2008). "Chapter 5: Genetics in Pharmacology: Twin Studies". Pharmacogenetics (2nd ed.). Oxford: Oxford University Press. pp. 107–8. ISBN 978-0-19-971216-8.
- ^ Falconer DS, Mackay TF (1998). Introduction to quantitative genetics (4th ed.). Essex: Longman Group, Ltd. ISBN 978-0-582-24302-6.
- ^ Mayhew, Alexandra J.; Meyre, David (2017-07-26). "Assessing the Heritability of Complex Traits in Humans: Methodological Challenges and Opportunities". Current Genomics. 18 (4): 332–340. doi:10.2174/1389202918666170307161450. ISSN 1389-2029. PMC 5635617. PMID 29081689.
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