Taxus Baccata

Four-time defending champion Esther Vergeer defeated Daniela Di Toro in the final, 6–0, 6–0 to win the women's singles wheelchair tennis title at the 2010 US Open.

1. Esther Vergeer (champion)
2. Sharon Walraven (semifinals)

	Quarterfinals							Semifinals							Finals
	1	Esther Vergeer	7	7
		Florence Alix-Gravellier	5	5
								1	Esther Vergeer	6	6
									Jiske Griffioen	1	0
		Jiske Griffioen	6	6
	WC	Mackenzie Soldan	1	1
															1	Esther Vergeer	6	6
																Daniela Di Toro	0	0
		Daniela Di Toro	6	7
		Aniek van Koot	3	62
									Daniela Di Toro	6	6
								2	Sharon Walraven	4	2
		Annick Sevenans	4	3
	2	Sharon Walraven	6	6

• Main Draw