Sycamore

by | Feb 6, 2018 | Large Trees

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Flestolol is a short-acting beta adrenergic receptor antagonist.[1]

Synthesis

ChemDrug Synthesis:[2][3] Patent:[4]

Acylation of acid chloride 2-Fluorobenzoyl chloride [393-52-2] (1) with glycidol (2) produces the ester 2,3-Epoxypropyl 2-Fluorobenzoate [85515-51-1] (3). Reaction of that intermediate with amine (2-Amino-2-methyl-propyl)-urea [87484-83-1] (4) obtained by reaction of 1,1-dimethylethylenediamine with urea, gives flestolol (5).

References

  1. ^ Quon, CY; Stampfli, HF (1993). "Biochemical characterization of flestolol esterase". Research communications in chemical pathology and pharmacology. 81 (3): 309–22. PMID 8235065.
  2. ^ Day, BW; Pento, JT; ACC-9089. Drugs Fut 1985, 10, 6, 447.
  3. ^ Kam, Sheung Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; O'Donnell, John P.; Stampfli, Herman F.; Sum, Check Y.; Anderson, William G. (1984). "[(Arylcarbonyl)oxy]propanolamines. 1. Novel .beta.-blockers with ultrashort duration of action". Journal of Medicinal Chemistry. 27 (8): 1007. doi:10.1021/jm00374a013. PMID 6146718.
  4. ^ Agustin Escobar, Dietmar M. Wagenknecht, Abu S. Alam, WO1985004581 (1985 to American Hospital Supply Corporation).



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