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Decaprenyl-phosphate phosphoribosyltransferase (EC 2.4.2.45, 5-phospho-alpha-D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase, 5-phospho-alpha-D-ribose 1-pyrophosphate:decaprenyl phosphate 5-phosphoribosyltransferase, DPPR synthase, Rv3806) is an enzyme with systematic name trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate:diphosphate phospho-alpha-D-ribosyltransferase.[1] This enzyme catalyses the following chemical reaction
- trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
This enzyme requires Mg2+. It is isolated from Mycobacterium tuberculosis.
References
- ^ Huang H, Scherman MS, D'Haeze W, Vereecke D, Holsters M, Crick DC, McNeil MR (July 2005). "Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-{alpha}-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesis". The Journal of Biological Chemistry. 280 (26): 24539–43. doi:10.1074/jbc.m504068200. PMID 15878857.
External links
- Decaprenyl-phosphate+phosphoribosyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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