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by | Mar 21, 2018 | Solidago

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VUF-8430 is a histamine agonist[1] selective for the H4 subtype.[2]

References

  1. ^ Smith FM, Haskelberg H, Tracey DJ, Moalem-Taylor G (2007). "Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury". Neuroimmunomodulation. 14 (6): 317–25. doi:10.1159/000125048. PMID 18401194. S2CID 23020760.
  2. ^ Lim, HD; Smits, RA; Bakker, RA; Van Dam, CM; De Esch, IJ; Leurs, R (2006). "Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist". Journal of Medicinal Chemistry. 49 (23): 6650–1. doi:10.1021/jm060880d. PMID 17154494.


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