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Sclerosis (also sclerosus in the Latin names of a few disorders) is a hardening of tissue and other anatomical features; it may refer to:
- Sclerosis (medicine), a hardening of tissue
- in zoology, a process which hardens forms sclerites, a hardened exoskeleton
- in botany, a process which hardens plant tissue by adding fibers and sclereids, resulting in sclerenchyma
- In economics, see: Eurosclerosis
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