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Chemical compound
Desmethylchlorotrianisene (DMCTA) is a nonsteroidal estrogen which is thought to be the major active metabolite of chlorotrianisene (CTA; TACE).[1][2] It is a 1:1 mixture of cis and trans isomers.[1][2] DMCTA is produced from CTA via mono-O-demethylation catalyzed by cytochrome P450 enzymes in the liver.[1][2] CTA is thought to act as a long-lasting prodrug of DMCTA.[1]
References
- ^ a b c d Ruenitz PC, Toledo MM (August 1981). "Chemical and biochemical characteristics of O-demethylation of chlorotrianisene in the rat". Biochem. Pharmacol. 30 (16): 2203–7. doi:10.1016/0006-2952(81)90088-5. PMID 7295335.
- ^ a b c Virgil Craig Jordan (1986). Estrogen/antiestrogen Action and Breast Cancer Therapy. Univ of Wisconsin Press. p. 212. ISBN 978-0-299-10480-1.
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