Rosmarinus

DADLE ([D-Ala², D-Leu⁵]-Enkephalin) is a synthetic opioid peptide with analgesic properties. Although it is often considered a selective δ-opioid receptor agonist, it also binds to the μ₁ subtype of μ-opioid receptors.

Treatment with DADLE results in transient depression of mean arterial blood pressure and heart rate.^[1][2]

Its peptide sequence is Tyr-D-Ala-Gly-Phe-D-Leu.

See also

• DAMGO
• DPDPE

References