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Chemical compound
MK6-83 is a chemical compound which acts as a channel opener for the TRPML family of calcium channels, with moderate selectivity for TRPML1 over the related TRPML2 and TRPML3 subtypes.[1][2][3]
See also
References
- ^ Kilpatrick BS, Yates E, Grimm C, Schapira AH, Patel S (October 2016). "Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx". Journal of Cell Science. 129 (20): 3859–3867. doi:10.1242/jcs.190322. PMC 5087663. PMID 27577094.
- ^ Morelli MB, Amantini C, Tomassoni D, Nabissi M, Arcella A, Santoni G (April 2019). "Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient's Survival". Cancers. 11 (4). doi:10.3390/cancers11040525. PMC 6521337. PMID 31013784.
- ^ Xia Z, Wang L, Li S, Tang W, Sun F, Wu Y, et al. (October 2020). "ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity". Antiviral Research. 182: 104922. doi:10.1016/j.antiviral.2020.104922. PMID 32858116.
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