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Chemical compound
Caramiphen is an anticholinergic drug used in the treatment of Parkinson's disease.[1] In combination with phenylpropanolamine it is used as a cough suppressant and nasal decongestant to treat symptoms associated with respiratory illnesses such as cold, allergies, hay fever, and sinusitis.[2] It was added to the British National Formulary in 1963, with a dosage of 10 to 20 mg. Side effects include nausea, dizziness, and drowsiness.[3]
It binds to the sigma-1 receptor with an IC50 value of 25 nM.[4]
References
- ^ "Caramiphen". drugs.com. Retrieved 26 September 2012.
- ^ "Caramiphen with phenylpropanolamine-oral, Ordrine AT, Rescaps-D, Tuss Vernade, Tusso-Gest". medicine.net. Archived from the original on 29 October 2012. Retrieved 26 September 2012.
- ^ Beirn SF, Lavelle S (May 1964). "To-day's drugs: Cough suppressants". British Medical Journal. 1 (5391): 1165–1167. doi:10.1136/bmj.1.5391.1165. PMC 1813498. PMID 14120813.
- ^ Musacchio JM, Klein M (June 1988). "Dextromethorphan binding sites in the guinea pig brain". Cellular and Molecular Neurobiology. 8 (2): 149–156. doi:10.1007/BF00711241. PMID 3044591. S2CID 33844132.
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