How Can We Help?
Butanilicaine is a local anesthetic. It is also known by the name Hostacaine.
Synthesis
The amide formation between 2-Chloro-6-Methylaniline [87-63-8] (1) and Chloroacetyl chloride (2) gives 2-Chloro-n-(2-chloro-6-methylphenyl)acetamide [6307-67-1] (3). Alkylation with N-Butylamine (4) completed the synthesis of Butanilicaine (5).
References
- ^ Haussler A, Ther L. [Chemical detection of hostacain]. Arzneimittelforschung. 1953;3(12):609-11.
- ^ Epstein, Elias; Kaminsky, Daniel (1958). "N-(Substituted Aminoacyl)-chloroanilines". Journal of the American Chemical Society 80 (8): 1892–1895. doi:10.1021/ja01541a028.
- ^ GB 726080 (1955 to Polymer Corp.)
- ^ GB 759744 (1956 to Cilag)
- ^ GB 782971 1957 to Hoechst AG.
- ^ G. Ehrhart et al., U.S. patent 2,912,460 (1959 to Hoechst).
Recent Comments