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Promanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in the mushroom genus Amanita.
Toxicology
Like other amatoxins, proamanullin is an inhibitor of RNA polymerase II. Promanullin has a specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).[1]
See also
References
- ^ Cochet-Meilhac M, Chambon P (June 1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim. Biophys. Acta. 353 (2): 160–84. doi:10.1016/0005-2787(74)90182-8. PMID 4601749.
External links
- Amatoxins REVISED Archived 2009-01-13 at the Wayback Machine
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| Subgenus Amanita |
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| Subgenus Amanitina |
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