Purple Passionflower – Passiflora incarnata

by | Dec 19, 2023 | Purple Passionflower

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MRS-1706 is a selective inverse agonist for the adenosine A2B receptor.[1] It inhibits release of interleukins and has an antiinflammatory effect.[2][3]

References

  1. ^ Li Q, Ye K, Blad CC, den Dulk H, Brouwer J, Ijzerman AP, Beukers MW (February 2007). "ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor". The Journal of Pharmacology and Experimental Therapeutics. 320 (2): 637–45. doi:10.1124/jpet.106.111203. PMID 17077318.
  2. ^ Vazquez JF, Clement HW, Sommer O, Schulz E, van Calker D (May 2008). "Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study". Journal of Neurochemistry. 105 (3): 904–9. doi:10.1111/j.1471-4159.2007.05191.x. PMID 18088370.
  3. ^ Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Dikov MM, Blackburn MR, et al. (June 2008). "Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells". Journal of Immunology. 180 (11): 7212–20. doi:10.4049/jimmunol.180.11.7212. PMC 3628765. PMID 18490720.


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