Purple Passionflower – Passiflora incarnata

by | Dec 19, 2023 | Purple Passionflower

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Isepamicin (also Isepamycin) is an aminoglycoside antibiotic.

It was patented in 1973 and approved for medical use in 1988.[1] It has been identified by the World Health Organization as a Critically Important Antimicrobial for human use.[2]

Synthesis

Thieme ChemDrug Synthesis:[3] Patent:[4]

Gentamicin B [36889-15-3] (1) benzyl N-[(2S)-3-(2,5-dioxopyrrolidin-1-yl)-2-hydroxy-3-oxopropyl]carbamate, PC70561099 (2) (3)

References

  1. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 508. ISBN 9783527607495.
  2. ^ "Critically important antimicrobials for human medicine" (PDF). World Health Organization. 2012.
  3. ^ Serradell, MN; Blancafort, P.; Roberts, PJ; Castaer, J.; SCH-21420. Drugs Fut 1979, 4, 7, 525.
  4. ^ John J. Wright, U.S. patent 4,029,882 (1977 to Merck Sharp and Dohme Corp).


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