Purple Passionflower – Passiflora incarnata

by NG | Dec 19, 2023 | Purple Passionflower

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4-Diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (or CDP-MEP, 4-diphosphocytidyl-2C methylerythritol 2-phosphate) is an intermediate in the MEP pathway of isoprenoid precursor biosynthesis.

It is formed by CDP-ME kinase (IspE) and is a substrate for 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF).^[1]

References

^ Narayanasamy P, Eoh H, Brennan PJ, Crick DC (2010). "Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF, a potential drug target". Chem Biol. 17 (2): 117–22. doi:10.1016/j.chembiol.2010.01.013. PMC 2837070. PMID 20189102.

Cholesterol and steroid metabolic intermediates

Mevalonate pathway

to HMG-CoA	Acetyl-CoA Acetoacetyl-CoA HMB HMB-CoA HMG-CoA
Ketone bodies	Acetone Acetoacetic acid β-Hydroxybutyric acid
to DMAPP	Mevalonic acid Phosphomevalonic acid 5-Diphosphomevalonic acid Isopentenyl pyrophosphate Dimethylallyl pyrophosphate
Geranyl-	Geranyl pyrophosphate Geranylgeranyl pyrophosphate
Carotenoid	Prephytoene diphosphate Phytoene

Non-mevalonate pathway

From Cholesterol
to Steroid hormones

Nonhuman

To Sitosterol	Cycloartenol Cycloeucalenol Obtusifoliol 4α-methylfecosterol Isofucosterol 24-Methylenelophenol Sitosterol More Phytosterols see here instead.
To Ergocalciferol	Fecosterol Episterol Ergostatrienol Ergostatetraenol Ergosterol Ergocalciferol

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