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Chemical compound
Chemical compound
Taspine is an alkaloid which acts as a potent acetylcholinesterase inhibitor and cicatrizant. It is found in various plants including Magnolia x soulangeana[1] and Croton lechleri.[2]
The first total synthesis was reported by T. Ross Kelly and Roger L. Xie in 1998.[3]
References
- ^ Rollinger, JM; Schuster, D; Baier, E; Ellmerer, EP; Langer, T; Stuppner, H (2006). "Taspine: Bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana". Journal of Natural Products. 69 (9): 1341–1346. doi:10.1021/np060268p. PMC 3526713. PMID 16989531.
- ^ Vaisberg, A.; Milla, M.; Planas, M.; Cordova, J.; De Agusti, E.; Ferreyra, R.; Mustiga, M.; Carlin, L.; Hammond, G. (2007). "Taspine is the Cicatrizant Principle in Sangre de Grado Extracted from Croton lechleri". Planta Medica. 55 (2): 140–143. doi:10.1055/s-2006-961907. PMID 2748730. S2CID 260251205.
- ^ Kelly, T. Ross; Xie, Roger L. (October 1998). "Total Synthesis of Taspine". The Journal of Organic Chemistry. 63 (22): 8045–8048. doi:10.1021/jo981099j.
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