Polemonium Reptans

by | Apr 16, 2018 | Polemonium Reptans

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RTI-352 is a phenyltropane that is used as a radiolabeling ligand for the DAT.[1]

RTI-352 is a geometric isomer of RTI-55 (β-CIT).[2]

Based on X-ray crystallography, this compound is in a tautomeric equilibrium residing mostly on the side of the boat-shaped conformer.

References

  1. ^ U.S. patent 6,358,492
  2. ^ Zhan, Yougen; Saindane, Amit M.; Scheffel, Ursula; Carroll, F. Ivy; Holmquist, Christopher R.; Kepler, John A.; Taylor, George F.; Kuhar, Michael J. (1997). "RTI-352: A 3α Analogue of RTI-55 as an in vivo dopamine transporter binding ligand". Synapse. 25 (4): 389–392. doi:10.1002/(SICI)1098-2396(199704)25:4<389::AID-SYN10>3.0.CO;2-Q. PMID 9097398.
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