Petunia

by | Mar 21, 2018 | Petunia

How Can We Help?
You are here:
< Back

AF-353 is a drug which acts as an antagonist of the P2X3 homotrimeric and P2X2/3 heterotrimeric forms of the P2X purinoreceptors. It has been found to block taste responses and has been proposed as an agent for masking the bitter taste of medications.[1][2][3]

See also

References

  1. ^ Gever JR, Soto R, Henningsen RA, Martin RS, Hackos DH, Panicker S, et al. (July 2010). "AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist". British Journal of Pharmacology. 160 (6): 1387–1398. doi:10.1111/j.1476-5381.2010.00796.x. PMC 2938810. PMID 20590629.
  2. ^ Vandenbeuch A, Larson ED, Anderson CB, Smith SA, Ford AP, Finger TE, et al. (March 2015). "Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice". The Journal of Physiology. 593 (5): 1113–1125. doi:10.1113/jphysiol.2014.281014. PMC 4358674. PMID 25524179.
  3. ^ Flammer LJ, Ellis H, Rivers N, Caronia L, Ghidewon MY, Christensen CM, et al. (May 2024). "Topical application of a P2X2/P2X3 purine receptor inhibitor suppresses the bitter taste of medicines and other taste qualities". British Journal of Pharmacology. doi:10.1111/bph.16411. PMID 38745397.


Categories
Table of Contents