Petasin is a natural chemical compound found in plants of the genus Petasites. Chemically, it is classified as a sesquiterpene and is the ester of petasol and angelic acid.

Petasin is believed to be responsible, at least in part, for the anti-inflammatory effects of common butterbur (Petasites hybridus) extracts.[1]

A 2021 study reported that petasin can inhibit tumor growth and metastasis in an animal model of cancer.[2]

References

  1. ^ Thomet, O; Wiesmann, UN; Schapowal, A; Bizer, C; Simon, HU (2001). "Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus". Biochemical Pharmacology. 61 (8): 1041–7. doi:10.1016/S0006-2952(01)00552-4. PMID 11286996.
  2. ^ Heishima, Kazuki; Sugito, Nobuhiko; Soga, Tomoyoshi; Nishikawa, Masashi; Ito, Yuko (2021). "Petasin potently inhibits mitochondrial complex I–based metabolism that supports tumor growth and metastasis". The Journal of Clinical Investigation. 131 (17): e139933. doi:10.1172/JCI139933. PMC 8409585.