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Samuel Smith Harrison (1780 – April 1853) was a member of the U.S. House of Representatives from Pennsylvania.

Samuel Smith Harrison was born in Virginia in 1780. He studied law, was admitted to the bar and practiced. He moved to Kittanning, Pennsylvania. He was elected as a Jacksonian to the Twenty-third and Twenty-fourth Congresses. He resumed the practice of law and died in Kittanning in 1853. Interment in Old Kittanning Cemetery.

• United States Congress. "Samuel Smith Harrison (id: H000276)". Biographical Directory of the United States Congress.
• The Political Graveyard