Pentas

In enzymology, a ribose-5-phosphate—ammonia ligase (EC 6.3.4.7) is an enzyme that catalyzes the chemical reaction

ATP + ribose 5-phosphate + NH₃

\rightleftharpoons

ADP + phosphate + 5-phosphoribosylamine

The 3 substrates of this enzyme are ATP, ribose 5-phosphate, and NH₃, whereas its 3 products are ADP, phosphate, and 5-phosphoribosylamine.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is ribose-5-phosphate:ammonia ligase (ADP-forming). This enzyme participates in purine metabolism.

References

Reem GH (November 1968). "Enzymatic synthesis of 5'-phosphoribosylamine from ribose 5-phosphate and ammonia, an alternate first step in purine biosynthesis". The Journal of Biological Chemistry. 243 (21): 5695–701. PMID 5699059.

Enzymes: CO CS and CN ligases (EC 6.1-6.3)
6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanine Arginine Asparagine Aspartate Cysteine D-alanine—poly(phosphoribitol) ligase Glutamate Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine
6.2: Carbon-Sulfur	Succinyl coenzyme A synthetase Acetyl—CoA synthetase Long-chain-fatty-acid—CoA ligase
6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Recent Comments