Interrupted Fern – Osmunda claytoniana

by | Dec 9, 2023 | NE Native Ferns

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L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D4 subtype, and has antipsychotic effects in animal models, though it was not effective in human trials.[1][2][3]

References

  1. ^ Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR (June 1997). "Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist". Trends in Pharmacological Sciences. 18 (6): 186–8. doi:10.1016/s0165-6147(97)01066-3. PMID 9226994.
  2. ^ Zhang K, Grady CJ, Tsapakis EM, Andersen SL, Tarazi FI, Baldessarini RJ (September 2004). "Regulation of working memory by dopamine D4 receptor in rats". Neuropsychopharmacology. 29 (9): 1648–55. doi:10.1038/sj.npp.1300491. PMID 15138447.
  3. ^ Moustgaard A, Hau J, Lind NM (2008). "Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats". Behavioral and Brain Functions. 4: 49. doi:10.1186/1744-9081-4-49. PMC 2577092. PMID 18945334.


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