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Chemical compound
Dicentrine is an aporphinic alkaloid found in several plant species, mainly from family Lauraceae, including Lindera megaphylla.[1] At high doses, dicentrine shows antinociceptive activity in a mouse model of pain.[2] It probably acts via a TRPA1-dependent mechanism.[2]
References
- ^ Huang, Ray-Ling; Chen, Chien-Chih; Huang, Yu-Lin; Ou, Jun-Chih; Hu, Cheng-Po; Chen, Chieh-Fu; Chang, Chungming (1998). "Anti-Tumor Effects of d-Dicentrine from the Root of Lindera megaphylla". Planta Medica. 64 (3): 212–215. doi:10.1055/s-2006-957411. PMID 9581516.
- ^ a b Montrucchio, Deise Prehs; Córdova, Marina Machado; Santos, Adair Roberto Soares (2013-07-04). "Plant Derived Aporphinic Alkaloid S-(+)-Dicentrine Induces Antinociceptive Effect in Both Acute and Chronic Inflammatory Pain Models: Evidence for a Role of TRPA1 Channels". PLOS ONE. 8 (7): e67730. Bibcode:2013PLoSO...867730M. doi:10.1371/journal.pone.0067730. ISSN 1932-6203. PMC 3701576. PMID 23861794.
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