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Chemical compound
Bay K8644 is a chemical compound that functions as an L-type calcium channel agonist. Bay K8644 is used primarily as a biochemical research tool for this effect.[2] It is a structural analog of nifedipine with positive inotropic activity, and as an aromatic it is highly lipid soluble.
Mechanism of action
Bay K8644 targets L-type voltage-gated calcium channels. It is the first positive inotropic agent shown to act specifically and directly on calcium channels.[3]
References
- ^ (±)-Bay K8644 at Sigma-Aldrich
- ^ CID 2303 from PubChem
- ^ Thomas, G; Chung, M; Cohen, CJ (January 1985). "A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent". Circ Res. 56 (1): 87–96. doi:10.1161/01.res.56.1.87. PMID 2578336.
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