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by | Mar 19, 2018 | Orange

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DR-4485 is a compound which acts as a potent and selective antagonist for the 5-HT7 receptor, with good oral bioavailability. It has been used to research the function of this still comparatively little studied serotonin receptor subtype.[1][2]

References

  1. ^ Kikuchi C, Suzuki H, Hiranuma T, Koyama M (January 2003). "New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability". Bioorganic & Medicinal Chemistry Letters. 13 (1): 61–4. doi:10.1016/s0960-894x(02)00842-9. PMID 12467617.
  2. ^ Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML (April 2009). "Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity". Journal of Medicinal Chemistry. 52 (8): 2384–92. doi:10.1021/jm8014553. PMID 19326916.
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