Tocofersolan (INN) or tocophersolan, also referred to as TPGS (for tocopherol polyethylene glycol succinate), is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is polyethylene glycol derivative of α-tocopherol that enables water solubility.
Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fats due to disease.[3] On 24 July 2009 the European Medicines Agency approved tocofersolan under the trade name Vedrop 50 mg/ml oral solution for the treatment of vitamin E deficiency due to digestive malabsorption in paediatric patients with congenital or hereditary chronic cholestasis, from birth (in term newborns) to 16 or 18 years of age (depending on the region).[4]
Tocofersolan is also used in cosmetics and pharmaceuticals as an antioxidant.[5]
References
- ^ "Vedrop 50 mg/ml oral solution - Summary of Product Characteristics (SmPC)". (emc). 19 June 2019. Retrieved 24 July 2020.
- ^ "Vedrop EPAR". European Medicines Agency (EMA). Retrieved 24 July 2020.
- ^ "Tocophersolan Oral". WebMD.
- ^ "Vedrop Summary of Product Characteristics" (PDF). European Medicines Agency.[permanent dead link]
- ^ Ash M, Ash I (2004). Handbook of Preservatives. Synapse Info Resources. p. 568. ISBN 1-890595-66-7.
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