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Chemical compound
Fenarimol, sold under the tradenames Bloc, Rimidin and Rubigan, is a fungicide which acts against rusts, blackspot and mildew fungi. It is used on ornamental plants, trees, lawns, tomatoes, peppers, eggplants, cucumbers and melons. It is mainly used to control powdery mildew. It works by inhibiting the fungus's biosynthesis of important steroid molecules (via blockade of the CYP51 enzyme).[2]
History
Fenarimol was developed by Eli Lilly and Company around 1971.[3]
As of early 2018, derivatives of this compound are being researched in an open source manner for possible treatment of eumycetoma.[4]
Synthesis
Fenarimol is made by the reaction of 2,4'-dichlorobenzophenone with an organolithium pyrimidine made via bromine-lithium exchange.[2]
References
- ^ a b c d e EU-Data.
- ^ a b Clayden J, Greeves N, Warren S (2005). Organic chemistry (Reprinted (with corrections) ed.). Oxford [u.a.]: Oxford Univ. Press. pp. 216. ISBN 978-0-19-850346-0.
- ^ GB 1218623 "Substituted-5-pyrimidine compounds "
- ^ Reynolds, Todd B.; Lim, Wilson; Melse, Youri; Konings, Mickey; Phat Duong, Hung; Eadie, Kimberly; Laleu, Benoît; Perry, Benjamin; Todd, Matthew H.; Ioset, Jean-Robert; van de Sande, Wendy W. J. (2018). "Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma". PLOS Neglected Tropical Diseases. 12 (4): e0006437. doi:10.1371/journal.pntd.0006437. ISSN 1935-2735. PMC 5940239. PMID 29698504.
External links
- Fenarimol in the Pesticide Properties DataBase (PPDB)
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GPERTooltip G protein-coupled estrogen receptor |
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