Monarda fistulosa

by | Dec 19, 2023 | Monarda

How Can We Help?
You are here:
< Back

F-11,461 is a drug that acts as an agonist of the 5-HT1A receptor (Ki = 1.36 nM) that has been used as a radioligand in PET studies. It possesses modest affinity for the 5-HT7 (Ki = 9.1 nM) and D4 (Ki = 8.5 nM) receptors, although the interaction of F-11,461 with these receptors is not detectable with PET due to their relative scarcity in the brain.[1]

See also

References

  1. ^ Kumar JS, Majo VJ, Hsiung SC, Millak MS, Liu KP, Tamir H, et al. (January 2006). "Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand". Journal of Medicinal Chemistry. 49 (1): 125–134. doi:10.1021/jm050725j. PMID 16392798.
Categories
Table of Contents