Monarda fistulosa

by | Dec 19, 2023 | Monarda

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AM-11245 is a drug which is a cannabinoid agonist from the classical cannabinoid family. It has high affinity and efficacy at both the CB1 and CB2 cannabinoid receptors, with a Ki of 0.4nM at both CB1 and CB2, and an EC50 of ~0.06nM at CB1 and 0.2nM at CB2, making it one of the most potent cannabinoid agonists identified to date.[1]

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References

  1. ^ Jiang S, Iliopoulos-Tsoutsouvas C, Tong F, Brust CA, Keenan CM, Raghav JG, et al. (April 2021). "Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists". Journal of Medicinal Chemistry. 64 (7): 3870–3884. doi:10.1021/acs.jmedchem.0c02053. PMID 33761251. S2CID 232355437.


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