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Chemical compound
AM-0902 is a drug which acts as a potent and selective antagonist for the TRPA1 receptor, and has analgesic and antiinflammatory effects.[1][2]
References
- ^ Schenkel LB, Olivieri PR, Boezio AA, Deak HL, Emkey R, Graceffa RF, et al. (March 2016). "Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity". Journal of Medicinal Chemistry. 59 (6): 2794–809. doi:10.1021/acs.jmedchem.6b00039. PMID 26942860.
- ^ Huang Y, Chen SR, Chen H, Pan HL (May 2019). "Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain". Journal of Neurochemistry. 149 (3): 381–398. doi:10.1111/jnc.14677. PMC 6483867. PMID 30716174.
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