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Chemical compound
TBPS (tert-butylbicyclophosphorothionate) is a bicyclic phosphate convulsant.[3] It is an extremely potent GABA receptor antagonist.[4][5]
See also
References
- ^ "tert-Butyl bicyclo[2.2.2]phosphorothionate".
- ^ Milbrath, Dean S.; Engel, Judith L.; Verkade, John G.; Casida, John E. (February 1979). "Structure-toxicity relationships of 1-substituted-4-alkyl-2,6,7-trioxabicyclo[2.2.2.]octanes". Toxicology and Applied Pharmacology. 47 (2): 287–293. doi:10.1016/0041-008x(79)90323-5. PMID 452023.
- ^ Trifiletti, Rosario R; Snowman, Adele M; Snyder, Solomon H (1984). "Solubilization and anionic regulation of cerebral sedative and convulsant receptors labeled with [35S] tert-butylbicyclophosphorothionate (TBPS)". Biochemical and Biophysical Research Communications. 120 (2): 692–9. doi:10.1016/0006-291x(84)91311-1. PMID 6329179.
- ^ Atack, J R; Ohashi, Y; McKernan, R M (2009). "Characterization of [35S]t-butylbicyclophosphorothionate ([35S]TBPS) binding to GABAA receptors in postmortem human brain". British Journal of Pharmacology. 150 (8): 1066–74. doi:10.1038/sj.bjp.0707186. PMC 2013908. PMID 17339834.
- ^ Im, Wha Bin; Pregenzer, Jeffrey F; Thomsen, Darrel R (1994). "Effects of GABA and various allosteric ligands on TBPS binding to cloned rat GABAA receptor subtypes". British Journal of Pharmacology. 112 (4): 1025–30. doi:10.1111/j.1476-5381.1994.tb13185.x. PMC 1910256. PMID 7952860.
Animal toxins | |
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Bacterial | |
Cyanotoxins | |
Plant toxins | |
Mycotoxins | |
Pesticides | |
Nerve agents | |
Bicyclic phosphates | |
Cholinergic neurotoxins | |
Other |
GABA receptor antagonists |
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GABA synthesis inhibitors | |
Glycine receptor antagonists | |
Glutamate receptor agonists | |
Convulsant barbiturates | |
Other |
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