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Chemical compound
TBPO is an extremely toxic bicyclic phosphate convulsant and GABA receptor antagonist. It is the most toxic bicyclic phosphate known, with an LD50 of 36 μg/kg in mice.[2]
See also
References
- ^ Zhao, C.; Hwang, S. H.; Buchholz, B. A.; Carpenter, T. S.; Lightstone, F. C.; Yang, J.; Hammock, B. D.; Casida, J. E. (27 May 2014). "GABAA receptor target of tetramethylenedisulfotetramine". Proceedings of the National Academy of Sciences. 111 (23): 8607–8612. Bibcode:2014PNAS..111.8607Z. doi:10.1073/pnas.1407379111. PMC 4060666. PMID 24912155.
- ^ Milbrath, Dean S.; Engel, Judith L.; Verkade, John G.; Casida, John E. (February 1979). "Structure-toxicity relationships of 1-substituted-4-alkyl-2,6,7-trioxabicyclo[2.2.2.]octanes". Toxicology and Applied Pharmacology. 47 (2): 287–293. doi:10.1016/0041-008x(79)90323-5. PMID 452023.
GABA receptor antagonists |
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GABA synthesis inhibitors | |
Glycine receptor antagonists | |
Glutamate receptor agonists | |
Convulsant barbiturates | |
Other |
Animal toxins | |
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Bacterial | |
Cyanotoxins | |
Plant toxins | |
Mycotoxins | |
Pesticides | |
Nerve agents | |
Bicyclic phosphates | |
Cholinergic neurotoxins | |
Other |
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