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Estrogen-related receptor beta (ERR-β), also known as ESRRB or NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (Estrogen Related Receptor Beta) gene .[5]
Function
ESRRB has been shown to be vital for the transition between a naïve pluripotent and primed pluripotent state in mammalian cells, and NANOG controls the expression of ESRRB in this scenario.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000119715 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021255 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: ESRRB estrogen-related receptor beta".
- ^ Festuccia N, Halbritter F, Corsinotti A, Gagliardi A, Colby D, Tomlinson SR, Chambers I (November 2018). "Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation". The EMBO Journal. 37 (21): e95476. doi:10.15252/embj.201695476. PMC 6213284. PMID 30275266.
Further reading
- Giguère V, Yang N, Segui P, Evans RM (January 1988). "Identification of a new class of steroid hormone receptors". Nature. 331 (6151): 91–94. Bibcode:1988Natur.331...91G. doi:10.1038/331091a0. PMID 3267207. S2CID 4275394.
- Sladek R, Beatty B, Squire J, Copeland NG, Gilbert DJ, Jenkins NA, Giguère V (October 1997). "Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene". Genomics. 45 (2): 320–326. doi:10.1006/geno.1997.4939. PMID 9344655.
- Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, et al. (December 1997). "Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern". The Journal of Clinical Endocrinology and Metabolism. 82 (12): 4258–4265. doi:10.1210/jcem.82.12.4470. PMID 9398750.
- Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, et al. (March 1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR". Gene. 228 (1–2): 101–109. doi:10.1016/S0378-1119(98)00619-2. PMID 10072763.
- Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM (December 1999). "Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2". Molecular Endocrinology. 13 (12): 2151–2162. doi:10.1210/mend.13.12.0381. PMID 10598588.
- Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE (April 2003). "Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition". Journal of Molecular Biology. 327 (4): 819–832. doi:10.1016/S0022-2836(03)00183-9. PMID 12654265.
- Kruijver FP, Balesar R, Espila AM, Unmehopa UA, Swaab DF (November 2003). "Estrogen-receptor-beta distribution in the human hypothalamus: similarities and differences with ER alpha distribution". The Journal of Comparative Neurology. 466 (2): 251–277. doi:10.1002/cne.10899. PMID 14528452. S2CID 86143014.
- Stossi F, Barnett DH, Frasor J, Komm B, Lyttle CR, Katzenellenbogen BS (July 2004). "Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors". Endocrinology. 145 (7): 3473–3486. doi:10.1210/en.2003-1682. PMID 15033914.
- Verdier-Sevrain S, Yaar M, Cantatore J, Traish A, Gilchrest BA (August 2004). "Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism". FASEB Journal. 18 (11): 1252–1254. doi:10.1096/fj.03-1088fje. PMID 15208259. S2CID 20159723.
- Smith LH, Coats SR, Qin H, Petrie MS, Covington JW, Su M, et al. (August 2004). "Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells". Circulation Research. 95 (3): 269–275. doi:10.1161/01.RES.0000136521.70093.f1. PMID 15217907. S2CID 43765339.
- Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA (February 2005). "Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease". The Journal of Clinical Endocrinology and Metabolism. 90 (2): 1041–1046. doi:10.1210/jc.2004-1211. PMID 15536156.
- Cheung CP, Yu S, Wong KB, Chan LW, Lai FM, Wang X, et al. (March 2005). "Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues". The Journal of Clinical Endocrinology and Metabolism. 90 (3): 1830–1844. doi:10.1210/jc.2004-1421. PMID 15598686.
- Zhou W, Liu Z, Wu J, Liu JH, Hyder SM, Antoniou E, Lubahn DB (February 2006). "Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta". The Journal of Clinical Endocrinology and Metabolism. 91 (2): 569–579. doi:10.1210/jc.2004-1957. PMID 16332939.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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