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Chemical compound
(Z)-4-Amino-2-butenoic acid[1] (CACA, cis-4-aminocrotonic acid) is a GABA receptor partial agonist selective for the GABAA-ρ (previously known as GABAC) subtype.[2][3][4]
References
- ^ a b cis-4-Aminocrotonic acid at Sigma-Aldrich
- ^ Qian, H; Dowling, JE (1996). "Selective agonists for GABAC receptors". Trends in Neurosciences. 19 (5): 190. doi:10.1016/0166-2236(96)85451-8. PMID 8723205. S2CID 208792634.
- ^ Duke, RK; Chebib, M; Balcar, VJ; Allan, RD; Mewett, KN; Johnston, GA (2000). "(+)- and (−)-cis-2-aminomethylcyclopropanecarboxylic acids show opposite pharmacology at recombinant rho(1) and rho(2) GABA(C) receptors". Journal of Neurochemistry. 75 (6): 2602–10. doi:10.1046/j.1471-4159.2000.0752602.x. PMID 11080214.
- ^ Reis, GM; Duarte, ID (2007). "Involvement of chloride channel coupled GABA(C) receptors in the peripheral antinociceptive effect induced by GABA(C) receptor agonist cis-4-aminocrotonic acid". Life Sciences. 80 (14): 1268–73. doi:10.1016/j.lfs.2006.12.015. PMID 17316706.
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