How Can We Help?
Diphepanol is a cough suppressant (antitussive).
Synthesis
Ex 1: The α-keto bromination of propiophenone [93-55-0] (1) gives 2-bromopropiophenone [2114-00-3] (2). Displacement of the halogen and hence amination with piperidine [110-89-4] gave alpha-Piperidinopropiophenone, CID:458526 (3). and addition of phenyl Grignard reagent to give the benzhydrol product, and hence Dihepanol (4).
See also
References
- ^ Moehre, H.; Kamper, Ch. Pharmazie, 1983 , vol. 38, # 8 p. 512 – 520.
- ^ L. Stein and E. Lindner, U.S. patent 2,827,460 (1958 to Hoechst)
Recent Comments