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The Premios 40 Principales for Best America Song is an honor presented annually at the Los 40 Principaless, a ceremony that recognizes excellence, creates a greater awareness of cultural diversity and contributions of Latino artists in the international scene.
This is a list of the Los Premios 40 Principales winners and nominees for Song of the Year.
| Year | Winner | Other nominees |
|---|---|---|
| 2012 |  Jesse & Joy — "¡Corre!"
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