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Folin's reagent or sodium 1,2-naphthoquinone-4-sulfonate is a chemical reagent used as a derivatizing agent to measure levels of amines and amino acids.[1] The reagent reacts with them in alkaline solution to produce a fluorescent material that can be easily detected.[2]
This should not be confused with Folin-Ciocalteu reagent, that is used to detect phenolic compounds.
The Folin reagent can be used with an acidic secondary reagent to distinguish MDMA and related compounds from PMMA and related compounds.[3][failed verification]
| Substance | Reaction |
|---|---|
| MDMA | Pink[3] |
| MDE | No Reaction[3] |
| MDA | Yellow[3] |
| BZP | Orange to red[3] |
| TFMPP | Pinkish red[3] |
| Methylone | No reaction[3] |
| Methamphetamine | Pink[3] |
| Amphetamine | Light orange[3] |
| PMA | Light Yellow[3] |
| PMMA | Light orange[3] |
| Ketamine | No reaction[3] |
| Mescaline | No reaction[3] |
| Cocaine | No reaction[3] |
| Aspirin | No reaction[3] |
| Sugar | No reaction[3] |
See also
- Pill testing
- Sullivan reaction
- Dille–Koppanyi reagent
- Froehde reagent
- Liebermann reagent
- Mandelin reagent
- Marquis reagent
- Mecke reagent
- Simon's reagent
- Zwikker reagent
References
- ^ Saurina J, Hernández-Cassou S (1994). "Determination of amino acids by ion-pair liquid chromatography with post-column derivatization using 1,2-naphthoquinone-4-sulfonate". Journal of Chromatography A. 676 (2): 311–9. doi:10.1016/0021-9673(94)80431-1. PMID 7921184.
- ^ Kobayashi Y, Kubo H, Kinoshita T (1987). "Fluorometric determination of guanidino compounds by new postcolumn derivatization system using reversed-phase ion-pair high-performance liquid chromatography". Anal. Biochem. 160 (2): 392–8. doi:10.1016/0003-2697(87)90066-2. PMID 3578768.
- ^ a b c d e f g h i j k l m n o p "Folin Reagent Testing Kit". Dancesafe. June 2015. Archived from the original on 11 September 2015. Retrieved 8 August 2015.
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