Humulus Lupulus

Cannabidiorcol (CBDO, CBD-C1, O-1821) is a phytocannabinoid found naturally in Cannabis in trace concentrations. It is related to cannabidiol, with the pentyl side chain shortened to a methyl group. Cannabidiorcol has low affinity for cannabinoid receptors and is mainly active as an agonist of the TRPV2 cation channel, through which it produces antiinflammatory effects,^[1] but can also promote tumorigenesis at high concentrations.^[2]

References

^ Laragione T, Harris C, Gulko PS (March 2023). "Combination therapy of a TRPV2 agonist with a TNF inhibitor achieves sustained suppression of disease severity and reduced joint damage". Clinical and Experimental Immunology. 211 (3): 233–238. doi:10.1093/cei/uxac124. PMC 10038320. PMID 36571199.
^ Huang R, Li S, Tian C, Zhou P, Zhao H, Xie W, et al. (November 2022). "Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma". British Journal of Cancer. 127 (8): 1424–1439. doi:10.1038/s41416-022-01896-2. PMC 9553907. PMID 35896815.

[pmid36571199-1] Laragione T, Harris C, Gulko PS (March 2023). "Combination therapy of a TRPV2 agonist with a TNF inhibitor achieves sustained suppression of disease severity and reduced joint damage". Clinical and Experimental Immunology. 211 (3): 233–238. doi:10.1093/cei/uxac124. PMC 10038320. PMID 36571199.

[pmid35896815-2] Huang R, Li S, Tian C, Zhou P, Zhao H, Xie W, et al. (November 2022). "Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma". British Journal of Cancer. 127 (8): 1424–1439. doi:10.1038/s41416-022-01896-2. PMC 9553907. PMID 35896815.

[1]

[2]

Humulus Lupulus

See also

References

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