Silandrone (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name) (developmental code name SC-16148), also known as testosterone 17β-trimethylsilyl ether or 17β-trimethylsilyltestosterone, as well as 17β-(trimethylsiloxy)androst-4-en-3-one, is a synthetic anabolic-androgenic steroid (AAS) and an androgen ether – specifically, the 17β-trimethylsilyl ether of testosterone – which was developed by the G. D. Searle & Company in the 1960s but was never marketed.[1] It has a very long duration of action when given via subcutaneous or intramuscular injection, as well as significantly greater potency than that of testosterone propionate.[2][3] In addition, silandrone, unlike testosterone and most esters of testosterone like testosterone propionate, is orally active.[4]
See also
References
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 642–. ISBN 978-1-4757-2085-3.
- ^ Saunders FJ (November 1966). "A singularly long-acting ether of testosterone". Proceedings of the Society for Experimental Biology and Medicine. 123 (2): 303–4. doi:10.3181/00379727-123-31472. PMID 5951069. S2CID 21363508.
- ^ Le Boeuf BJ, Allen JL (1970). "Prolonged reinstatement of sexual behavior in castrated male rats with an ether of testosterone, SC-16148". Hormones and Behavior. 1 (2): 121–125. doi:10.1016/0018-506X(70)90004-8.
- ^ Chinn LJ (1969). The Chemistry and Biochemistry of Steroids. Geron-X. p. 97. ISBN 9780876720035.
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