Fluminorex is a centrally acting sympathomimetic which is related to other drugs such as aminorex and pemoline. It was developed as an appetite suppressant by McNeil Laboratories in the 1950s.[1]

Synthesis

Synthesis:[2] Patent (Ex XV):[3]

2-amino-1-[4-(trifluoromethyl)phenyl]ethanol [776-02-3] (1) cyanogen bromide [506-68-3] (2)

See also

References

  1. ^ US Patent 3278382 - 2-amino-5-aryloxazoline compositions and methods of using same
  2. ^ Poos, G. I., Carson, J. R., Rosenau, J. D., Roszkowski, A. P., Kelley, N. M., McGowin, J. (May 1963). "2-amino-5-Aryl-2-oxazolines. Potent New Anorectic Agents". Journal of Medicinal Chemistry. 6 (3): 266–272. doi:10.1021/jm00339a011.
  3. ^ Poos George Ireland, U.S. Patent 3,278,382 (1966 to Janssen Pharmaceuticals Inc).